Translations:Advanced Field Epi:Manual 2 - Diagnostic Tests/211/en

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Sometimes a new test may appear to be more sensitive (or specific) than the existing "gold standard" test (for example, new DNA-based tests compared to conventional culture). In this situation, the new test will find more (or fewer) positives than the reference test and careful analysis is required to determine whether this is because it is more sensitive or less specific. Even then, it is often not possible to reliably estimate sensitivity or specificity because there is no fixed reference point, so it may only be possible to say that the new test is more sensitive (or specific) than the old test, without specifying a value.