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Any control or eradication program depends on the implementation of one or more control measures to interrupt transmission and reduce prevalence. While it is possible to control and even eradicate diseases with imperfect tools (for example brucellosis, TB), the more effective the measures are, the more likely a program is to succeed. The less that is known about disease transmission and on-farm control measures, or the harder it is to control on-farm, the more difficult it will be to control the disease on a regional or national level. Measures must also be effective at preventing spread between farms, as well as at reducing or preventing transmission on infected farms.