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After completion of history taking and physical examination, an investigator should be able to make a list of possible reasons for the clinical signs that an animal shows. It may be possible to reduce the size of this list by submitting relevant sample for laboratory examination. For example, a cow with a fever and noticeably dark urine may have anaplasmosis, or a kidney infection, or the urine colour may be unrelated to the fever. It will help to get a urine sample for laboratory examination. A blood sample may be of help in diagnosis of a blood parasite or other infection.