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Diseases that are mainly sub-clinical or for which diagnostic tests have a poor sensitivity are likely to be difficult and expensive to detect, making the reliable identification of cases and implementation of control measures difficult. Diseases which can be detected through screening of routinely available samples or by simple testing at the herd/flock level (for example abattoir screening, bulk milk samples) are more suited to an effective program than diseases which require on-farm testing of large numbers of individual animals for the identification of infected individuals and/or herds/flocks.