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The initial investigation of Mad Cow Disease or Bovine Spongiform Encephalopathy (BSE) in the United Kingdom suggested that the disease was likely to have been spread through contamination of cattle feed products with meat and bone meal. Preventative measures involving a ban of feeding ruminant-derived protein were identified from initial epidemiologic investigations and put in place well before the agent was identified. Years later additional research identified the causal agent (a prion) and confirmed that the initial recommendations were effective in preventing further spread of the disease.}}